Bioassay Technology Laboratory's MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
Catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7: this enzyme cleaves type III collagen more slowly than type I.:cofactor:Binds 2 zinc ions per subunit.:cofactor:Binds 3 calcium ions per subunit.:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion: thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.:enzyme regulation:Cannot be activated without removal of the activation peptide.:Can degrade fibrillar type I: II: and III collagens.:Belongs to the peptidase M10A family.:Contains 4 hemopexin-like domains.:subcellular location:Stored in intracellular granules.:tissue specificity:Neutrophils.: